Associate Scientist, Bioanalytical Sciences
ASSOCIATE SCIENTIST,
BIOANALYTICAL SCIENCES
ABOUT THE COMPANY
Aurora Therapeutics is transforming the development and approval of personalized gene-editing therapies for patients with rare diseases. The company utilizes advanced CRISPR technologies alongside innovative regulatory and manufacturing frameworks to streamline the path for multiple mutation-specific treatments. Aurora's innovative approach overcomes traditional barriers to delivering therapies for rare mutations, enabling CRISPR treatments to serve larger patient populations. For more details, visit auroratherapeutics.com.
Aurora was founded by Jennifer Doudna, Ph.D., CRISPR co-inventor and Nobel Laureate, and Fyodor Urnov, Ph.D., a leader in translating genome-editing science into human therapeutics. Our experienced leadership team led by Edward M. Kaye, M.D., brings deep expertise in both gene editing and clinical development.
THE OPPORTUNITY
Aurora is expanding our research team and seeking an Associate Scientist in Bioanalytical Sciences. We're looking for a motivated scientist to join our team and contribute directly to advancing our first therapeutic program. This is an opportunity to make meaningful contributions at a critical stage of our pipeline development.
This is a full-time, on-site role for an Associate Scientist in Bioanalytical Sciences, based in Cambridge, MA.
RESPONSIBILITIES
Develop, qualify, and validate PK/PD assays (RT-qPCR/ddPCR, ELISA/MSD, NGS-based editing readouts) following ICH M10 and FDA bioanalytical guidance to support preclinical studies
Process and analyze mouse and NHP tissues, optimizing workflows for nucleic acid and protein extraction from liver and other organs, as well as downstream molecular analysis
Author and maintain assay protocols, SOPs, and technical reports to GLP-ready standards
Support transfer of qualified assays to external CRO partners and troubleshoot technical issues
Generate and analyze bioanalytical data to inform lead selection, dose optimization, and study design
Maintain rigorous electronic lab notebooks, sample inventories, and data documentation
QUALIFICATIONS
Required:
B.S. with 5+ years or M.S. with 3+ years of relevant laboratory experience in molecular biology, biochemistry, genetics, or a related discipline
Hands-on expertise with LBA and PCR assay development, optimization, and troubleshooting for protein and mRNA quantification
Proficiency in additional molecular and immunoassay techniques: DNA/RNA isolation from tissues, RT-qPCR/ddPCR, NGS, ELISA or MSD platforms
Experience processing mouse and/or NHP tissues for downstream molecular analysis
Experience writing detailed protocols and technical documents
Strong organizational skills with meticulous attention to data integrity and documentation
Preferred:
Biotech or pharmaceutical industry experience, particularly in preclinical bioanalysis
Familiarity with ICH M10 guidelines and regulated bioanalytical method development
Tissue processing experience with high-throughput platforms (e.g., bead-based homogenization, automated extraction systems, 96-well workflows)
Experience with CRISPR-based gene editing assays including NGS library prep for editing quantification
Cell culture experience including sterile technique, transfection, and primary cell handling. Experience with primary human hepatocytes is preferred.
Experience with CRO management or assay technology transfer
Exposure to LNP-based in vivo gene editing therapeutics
To apply, submit your resume/CV and cover letter to careers@auroratherapeutics.com
Aurora is an equal opportunity employer, providing equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Aurora complies with applicable state and local laws governing nondiscrimination in employment.